How Effective Are Antidepressants?

Joseph F. Goldberg, MD; Mark H. Pollack, MD; Andrew A. Nierenberg, MD

Posted: 03/11/2010

Editor’s Note:

In January 2010, JAMA published a meta-analysis by Fournier and colleagues[1] concluding that the efficacy of certain antidepressants increases with disease severity. The report further concludes that the benefits of these agents may be minimal or nonexistent in patients with mild-to-moderate symptoms. Given the potentially significant clinical implications of these findings, we’ve asked 3 experts in depression to weigh in on the legitimacy of the study and how such data might affect practice.